RAF Typhoon FGR4s have conducted a mission with French aircraft in a combined operation targeting an subterranean weapons facility in Syrian territory operated by the Daesh militant organization, per a report from the UK's MoD.
The site, pinpointed through intelligence, was thought to be housing weapons and explosive materials, the statement said, and was located in mountains just to the north of the historic site of Palmyra in Syria's central region.
"Our fighter planes employed Paveway IV guided bombs to target a number of access tunnels down to the depot... early reports indicate the strike was effective," the ministry announced.
There was no indication of any civilian casualties in the attack late on Saturday and each participating jet returned to base without incident, the defence officials confirmed.
The Typhoon fighters were assisted by a Voyager tanker plane.
IS - also known as the so-called Islamic State - enforced militant control over parts of Iraq and Syria until 2019.
"This action shows our UK leadership, and resolve to operate in unison with our allies, to stamp out any revival of the terrorist group and their harmful and extremist ideologies in the region," the British Defence Secretary the Defence Secretary said.
RAF aircraft have carried out surveillance missions over Syrian airspace to "forestall any efforts to regroup" of the group subsequent to its routing at the climactic battle in Baghuz in the year 2019, the ministry said.
"I want to thank the personnel of our armed forces who took part in this strike for their expertise and their courage," the Defence Secretary commented. "Including them were thousands of British personnel on duty over Christmas and New Year. This mission, to take out dangerous terrorists who threaten our way of life, highlights how our armed forces are prepared to act, throughout the year, ensuring Britain's security at home and strong abroad."
During December, the United States armed forces carried out what it described as a "major assault" targeting Islamic State objectives in the country, after an attack killed two US servicemembers and a civilian interpreter in the Palmyra area.
The United Nations says Islamic State still boasts an estimated 5,000 to 7,000 combatants in Iraq and Syria.